Kidney disease 24 hours urine test common sense

The core suggests that urinary protein has a toxic effect on glomerular mesangial cells, the patient will enter a large number of plasma proteins in the glomerular mesangial area after renal failure, the deposition of these macromolecules in the mesangial area can cause Mesangial cell damage, mesangial cell proliferation and mesangial matrix formation increased, leading to glomerular sclerosis;

24-hour urine test, is a commonly used clinical examination of kidney disease, mainly for the initial judgment of kidney disease, as well as the general location of the patient's condition. According to the results of urine test, and the normal value of the comparison, you can draw the corresponding conclusions. Of course, there are other factors that cause differences in urine test results, so regular checks are important. Next, the authority of experts for everyone to explain: 24 hours of kidney disease common sense of urine test.
What is a 24-hour urine test?
Hourly urine test is a collection of 24 hours to collect all the urine to do qualitative test of a urine detection method.
Clinical significance of 24 - hour urine test
Clinically, to determine whether the occurrence of nephropathy, and more through urine routine examination of urinary protein qualitative and quantitative indicators of two comprehensive judgments. Urine protein qualitative indicator is often said that the urine protein is negative or positive. If the urine protein test results are positive, the degree of response to nephropathy to see it with a few +. And quantitative determination of urinary protein is more accurate response to the subjects of renal function, commonly used diagnostic indicators that is 24 hours urine protein quantification.
24 hours urine urine protein detection
Urinary protein is involved as an independent factor in the process of renal disease, urinary protein can also damage the kidneys. Performance in the following areas:
1, urinary protein on glomerular mesangial cells with toxic effects, patients into renal failure, there will be a large number of plasma protein deposition in the glomerular mesangial area, the macromolecular material deposition in the mesangial area can cause Membrane cell damage, mesangial cell proliferation and mesangial matrix formation increased, leading to glomerular sclerosis;
2, urinary protein can damage the tubulointerstitial, normal glomerular filtration of a small amount of small molecular protein is close to the renal tubular epithelial cell reabsorption, in the lysosome within the decomposition. Pathological conditions, increased glomerular permeability of a large number of plasma protein leakage into the renal tubular cavity, and proximal renal tubular epithelial cells overweight reabsorption of albumin lead to increased intracellular lysosomal activity, can cause cell damage;
3, a large number of proteinuria to renal tubular reabsorption of protein increased, to promote the production of ammonia increased, and renal tissue in the formation of ammonia in the progressive interstitial lesions also play a role. In addition, reabsorption and digestion of large amounts of protein to be extra energy, which can cause small tube cells hypoxia, oxygen free radicals increased, causing tubule cell damage.
Treatment of kidney disease, to a large extent, the treatment of good or bad, depending on the patient's choice of treatment, of course, timely detection of the disease is also very important. It is not difficult to see from this, if the conditions permit, it is recommended to do a regular physical health check, and 24-hour urine test, is a check for a viable way.